Capitals indicate life threatening, underlines indicate most frequent. As in any fire, wear selfcontained breathing apparatus pressuredemand niosh approved or. Assess patient for symptoms of hyponatremia headache, tachycardia, lassitude, dry mucous membranes, nausea, vomiting, muscle cramps or hypernatremia. Find information on alendronate binosto, fosamax in daviss drug guide including dosage, side effects, interactions, nursing. It is soluble in water, very slightly soluble in alcohol, and practically insoluble in chloroform fosamax tablets for oral administration contain 91. Alendronate sodium is a white, crystalline, nonhygroscopic powder. Alendronate daviss drug guide for rehabilitation professionals. The efficacy of alendronate for postmenopausal women. Indications treatment and prevention of osteoporosis in postmenopausal women treatment of men with osteoporosis. Your medicine is called fosamax once weekly 70mg alendronate sodium. There is no evidence that any metabolism takes place. Get a printable copy pdf file of the complete article 1.
Normally your bones are being rebuilt all the time. Alendronate is used to treat osteoporosis caused by menopause, steroid use, or gonadal failure. Some of the medicines that may lead to alendronate drug interactions include. Many interactions can make alendronate less effective, while others may increase the risk of side effects. Daviss drug guide for nurses, sixteenth edition delivers all of the information you need to. Fosamax pregnancy category c drug classes bisphosphonates calcium regulator therapeutic actions slows normal and abnormal bone resorption without inhibiting bone formation and mineralization.
Women at low risk for fracture after 5 years may be able to take a break. Alendronate works only if taken on an empty stomach. Treatment and prevention of osteoporosis in postmenopausal. Boneresorption inhibitor pregnancy risk category c action impedes bone resorption by inhibiting osteoclast activity, absorbing calcium. Transient distribution into soft tissue is rapidly followed by redistribution to bone or urinary excretion. Use is often recommended together with vitamin d, calcium supplementation, and lifestyle changes common side effects include constipation, abdominal pain, nausea, and acid reflux. Start with low impact or aquatic programs in patients with extensive demineralization, and increase exercise intensity slowly to prevent fractures. Fosamax alendronate sodium tablets and fosamax alendronate sodium oral solution, merck and co inc, medication guide created date. Alendronate sodium information, side effects, warnings and. Fosamax alendronate sodium is a bisphosphonate that acts as a specific inhibitor of osteoclastmediated bone resorption. Once weekly 70mg tablets alendros once weekly 70mg tablets but will.
Docusate sodiumsenna pericolace, senna plus daviss. Fosamax alendronate sodium dose, indications, adverse. Fosamax alendronate sodium is a bisphosphonate that acts as a specific inhibitor of osteoclast mediated bone resorption. Alendronate may also be used for purposes not listed in this medication guide. Highlights of prescribing information inability to. Alendronate is approximately 78% bound to protein in human plasma. Fosamax is prescribed for treating osteoporosis, bone pain from diseases such as breast cancer, multiple myeloma, and pagets disease. Bisphosphonates are synthetic analogs of pyrophosphate that bind to the hydroxyapatite found in bone. Alendronate oral tablet is a prescription drug thats available as the brandname drugs fosamax and binosto. Once alendronate is bound to bone, the halflife is more than 10 years. To view the entire topic, please sign in or purchase a subscription. Alendronate fosamax is in a drug class of medications called bisphosphonates. Treatment of postmenopausal osteoporosis with slowrelease sodium fluoride.
To view other topics, please sign in or purchase a subscription. Alendronate is also used to treat pagets disease of bone. It does, however, localize preferentially to resorption sites of active bone turnover and has minimal to no interference with bone mineralization. Contains nonbinding recommendations draft guidance on. Drug interactions with alendronate senior health home page. Bisphosphonates for the treatment of osteoporosis anzbms. Alendronate is a bisphosphonate that inhibits osteoclastmediated bone resorption. Institute weightbearing and resistance exercises as tolerated to maintain or increase bone mineral density. Capitals indicate lifethreatening, underlines indicate most frequent. Alendronate sodium is chemically described as 4amino1hydroxybutylidene bisphosphonic acid monosodium salt trihydrate. Wait at least 30 minutes preferably 1 to 2 hours after taking the medication before you eat or drink anything other than plain water. This draft guidance, once finalized, will represent the food and drug administration s fdas. If your institution subscribes to this resource, and you dont have a myaccess profile, please contact your librarys reference desk for information on how to.
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